There are a few reports here, I think only 2-3 people have confirmed it, most haven't tried it I guess.
Some reports from ShellyB: http://pherotruth.org/Thread-Uh-what-are...0#pid55370

I remembered it out of the blue, I had put it in my todo notes but forgot about it.I may add it in my next order.Has anyone tried it at 200+mcg on skin and spend a reasonable time with a female?

Here a thread from the RPF with reviews from those using Pansterone (1.25mg of Preg. + 1.25mg DHEA per drop):

https://raypeatforum.com/community/threa...-mix.7426/

Suggested dose is 4 drops, so that would be around 5mg of DHEA.

(03-06-2019 8:59 AM)theLaw Wrote:  Here a thread from the RPF with reviews from those using Pansterone (1.25mg of Preg. + 1.25mg DHEA per drop):

https://raypeatforum.com/community/threa...-mix.7426/

Suggested dose is 4 drops, so that would be around 5mg of DHEA.

I've seen reports that these drops contain DMSO and that causes bad breath in some people. Do you know if this is still a problem?

Edit: Found answer to my own question on post #1138

Quote:Pansterone does not have DMSO any more. Now we have 2 options for solvents to choose from - SFA//ethanol and tocopherol/MCT. TyroMax is an NDT product and may contain additional substances present in the thyroid gland such as T1, T2, thyroglobulin, calcitonin, etc. Synthetic thyroid products contains only T4/T3.

Edit: Found another quote - post #840

Quote:The SFA ester is just something that studies claim to have as good absorption as DMSO if used in the same proportion when mixed with alcohol. So, the solvent changes from DMSO+ethanol to SFA esters + ethanol. No smell or aftertaste, and no skin irritation, so it should be a win-win for everybody.

Edit: One more quote - post #1072

Quote:Neither one, since it one was preferable to the other we would have only that one. Both have pros/cons. Some people like the tocopherol/MCT version more for sublingual/buccal application since the alcohol in the SFA version stings/burns the mouth. The SFA version seems to absorb better through the skin though.

(03-06-2019 8:59 AM)theLaw Wrote:  Here a thread from the RPF with reviews from those using Pansterone (1.25mg of Preg. + 1.25mg DHEA per drop):

https://raypeatforum.com/community/threa...-mix.7426/

Suggested dose is 4 drops, so that would be around 5mg of DHEA.

Law, there is a difference between DHEA and DHEA-S. There is the pricing; DHEAS is $170 for 10mg. While DHEA is $47 for a gram. The obvious is the formula. DHEA sulfate is a metabolite of DHEA produced by the addition of a sulfate group catalyzed by sulfotransferase enzymes.

(03-06-2019 7:35 AM)stefdude Wrote:  There are a few reports here, I think only 2-3 people have confirmed it, most haven't tried it I guess.
Some reports from ShellyB: http://pherotruth.org/Thread-Uh-what-are...0#pid55370

I remembered it out of the blue, I had put it in my todo notes but forgot about it.I may add it in my next order.Has anyone tried it at 200+mcg on skin and spend a reasonable time with a female?

Thanks for the link. I read some of the thread and it's hard to believe that after seven years this is being revisited.

This is because a lack of reporting. People try things and then when it fails they don't report back.

I would be more inclined (knowing that there is so much non reporting here) to believe that it was tried already and the results were negative.

(03-06-2019 12:55 PM)Paradox Wrote:  Law, there is a difference between DHEA and DHEA-S. There is the pricing; DHEAS is $170 for 10mg. While DHEA is $47 for a gram. The obvious is the formula. DHEA sulfate is a metabolite of DHEA produced by the addition of a sulfate group catalyzed by sulfotransferase enzymes.

Excellent point! Thanks for the clarification.

I think that some of the DHEA is converted to DHEA-S, but when used as a pheromone, it might be a different animal.

(03-06-2019 4:13 PM)theLaw Wrote:  Excellent point! Thanks for the clarification.

I think that some of the DHEA is converted to DHEA-S, but when used as a pheromone, it might be a different animal.

DHEA does not convert to DHEA-S in the body (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427309/)

(03-06-2019 4:52 PM)Paradox Wrote:  DHEA does not convert to DHEA-S in the body (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427309/)

Link you posted is dead.

Quote from this thread on the RPF:

https://raypeatforum.com/community/threa...els.14019/

Quote:Thyroid is a major factor in that young person response, because the ability to synthesize pregnenolone/DHEA depends on it. Also, the activity of the enzyme 17,21-lyase depends on cytochrome B5, which depends on metabolism more than anything else. Interestingly, aside from thyroid, DHEA itself is a potent inducer of cytochrome B5 in HED of just 10mg-12mg daily, so it stimulates its own synthesis and allows for even better counter-cortisol response.
When supplementing with DHEA in doses under 15mg daily the vast majority of it gets metabolized into downstream hormones and very little floats around as either DHEA or DHEAS. If a high dose of DHEA is taken orally then the excess that cannot be immediately metabolized gets converted into DHEAS. So, for most people exogenous DHEA will not stay as DHEA unless it is taken for several months (as we discussed) at which point the tissues will be saturated with DHEA and then serum levels will start to rise and thus will trigger increase in DHEAS as well.

Try this one (https://www.google.com/url?sa=t&rct=j&q=...imAWtgiw),

I should look deeper into DHEAS

(03-06-2019 7:37 PM)Paradox Wrote:  Try this one (https://www.google.com/url?sa=t&rct=j&q=...imAWtgiw),

I should look deeper into DHEAS

The link is to a study about DHEA converting into steroid hormones. Didn't seen anything to indicate that it couldn't convert into DHEA-S.