Just got a bottle of this today.

(02-28-2015 3:56 PM)dorfmeister Wrote:  Just got a bottle of this today.

Anything interesting to note when using?

I believe androsterone sulfate will perform the same as androsterone for our purposes. From a chemistry point of view, all the sulfate group does is enhance solubility in polar solvents. Since regular androsterone is already perfectly soluble at the concentrations used in pheromone products, it probably doesn't make a difference.
It is also possible that androsterone sulfate is cheaper to synthesize than androterone.

(08-01-2015 11:56 AM)eldros Wrote:  I believe androsterone sulfate will perform the same as androsterone for our purposes. From a chemistry point of view, all the sulfate group does is enhance solubility in polar solvents. Since regular androsterone is already perfectly soluble at the concentrations used in pheromone products, it probably doesn't make a difference.
It is also possible that androsterone sulfate is cheaper to synthesize than androterone.

You'd think, but this isn't even remotely the case. Test the sulfate forms of common molecules and you can expect drastically different results.

(08-01-2015 12:01 PM)Ekscentra Wrote:  You'd think, but this isn't even remotely the case. Test the sulfate forms of common molecules and you can expect drastically different results.

http://press.endocrine.org/doi/10.1210/e...%3Dpubmed&
It appears that the sulfation of steroids is basically a form of pre-steroid (which like I said before, enhances solubility). Once the sulfated steroid enters the blood stream and cells, the sulfate group is the cleaved to activate the steroid.
This seems irrelevant in the context of pheromones.
This is just IMHO. I'm no pheromone signalling expert.

(08-01-2015 12:10 PM)eldros Wrote:  http://press.endocrine.org/doi/10.1210/e...%3Dpubmed&
It appears that the sulfation of steroids is basically a form of pre-steroid (which like I said before, enhances solubility). Once the sulfated steroid enters the blood stream and cells, the sulfate group is the cleaved to activate the steroid.
This seems irrelevant in the context of pheromones.
This is just IMHO. I'm no pheromone signalling expert.

Perhaps not completely irrelevant, though I'm no expert at chemistry, nor pharmacology.

I can confirm from experience that the subjective effects of Androsterone Sulfate drastically differ from Androsterone itself, however.

(08-01-2015 12:10 PM)eldros Wrote:  I'm no pheromone signalling expert.

Unless there is a secret science about it, when it comes to human, there is not already such a thing as a pheromone signaling expert.

(08-01-2015 11:56 AM)eldros Wrote:  I believe androsterone sulfate will perform the same as androsterone for our purposes. From a chemistry point of view, all the sulfate group does is enhance solubility in polar solvents. Since regular androsterone is already perfectly soluble at the concentrations used in pheromone products, it probably doesn't make a difference.
It is also possible that androsterone sulfate is cheaper to synthesize than androterone.

I must apologize for the intrusion but these are the posts that confuse both vets and noobs alike.

Want to do some Androsterone testing?

Go out in public for 2 hours with 20mcg of A.Androsterone on and wash it off.
Then put on 20mcg of Androsterone.S for the same amount of time and tell us later your result. If you use the same fix and concentration for both molecules you will see there is a rather large difference.
Large enough to warrant writing this post for.

I am not hacking or belittling you. We welcome the ambition and drive for new ideas.
Mac and cheese does not taste like macdonalds just because they both contain 'mac'

Test first. Talk later.

I'm interested in this molecule. Anyone has direct experience to share?

I have some. I'll wear it today.