(02-12-2016 1:52 PM)andromun Wrote: Hi Ekscentra I always enjoy reading your posts, no doubt you're very smart and know your chemistry.
I was very interested in your view of Alpha-THDOC and Pregnanolone >> are you stating that these two usually fuck up a mix with other components like Androstenone, Androsterone or nols?
I remember you saying in another post that alpha-thdoc is like a bridge molecule giving a blend more synergy. Pregnanolone from my understanding acts like a spotlight on the user...attention grabbing.
If you think that Alpha-THDOC and Pregnanolone hinder pheromone blends...is that why you are not a fan of PheromoneXS?
I believe they do cancel out the effects of a blend. Rate of diffusion, skin chemistry, etc. will effect this, but at some point A-THDOC and Pregnanolone derivatives seem to cancel out the effects of a blend.
Alpha-THDOC still seemingly has the ,bridge molecule" benefit, but it comes at a heavy price. Regardless, Iso E Super and relatives along with all of the P9x series are capable of producing similar effects without the downsides of A-THDOC.
I think you're thinking of Pregnenolone? That too is a GABA blocker, so this may factor in as well. The depression caused by Pregnenolone was too much for me to notice any other properties. Did dbot not mention Pregnenolone overwhelming the mix at some point, preventing other molecules from working properly? This would be consistent with blockage of GABA.
If I'm right, this might be one of the only reasons I don't like PXS. Steve putting too much faith in a molecule that ultimately detracts from his mixes. I'd be willing to give PXS yet another shot were they to remove the GABA blockers. Their cover scents are still atrocious, though!
And for what it's worth, I don't know much at all about chemistry. Pharmacology I have some working understanding of. This was a realization I've come through with personal experience. Once vendors start looking into it, we may be able to solve most or all of the constistency issues some members have been experriencing on these boards, not to mention those mixes often reported to do nothing at all. I'd consider this the most important step in getting back to the mixes of old.
Lastly, I should mention: I've been coming a long way formulating my own mixes. The only things I've been avoiding are the GABA blockers, with both the known common molecules and many novel molecules being put to use - consistency has been absolutely top-notch with testers so far. If it's not the GABA blockers, I can't imagine what the problem might be.