12-12-2011, 12:23 AM
General Summary for molecule E (5-Pregnen-3beta-ol-20-one potassium Sulfate)
--- will revisit & edit to format this thread properly and summarize results ---
General Discussion:
This compound was of interest to me due to it's similarity to pregnenolone, which seems to have some moderate pheromone potency. This is the potassium sulfate salt of Pregnenolone. The difference between the alkali metal (potassium or sodium) in the compound seems to make little difference.
It seems as if sulfated derivatives of known pheromones can have some interesting behavior. The addition of the sulfate molecule to the 3rd carbon in A-ring (3-sulfate instead of 3-hydroxy) produces unpredictable changes that cannot be theorized before actual experience. Sometimes, the sulfated pheromones produce better effects, as in the case of sulfating DHEA to obtain DHEAS.
I was hoping Pregnenolone would follow the same structure-activity logic as DHEA is to DHEAS. No such luck here it seems.
Interestingly, the solution of this compound in alcohol has turned a pinkish hue after sitting in the lab fridge for several months.
P.S. To learn more about structure activity relationships, please visit this link. This is the backbone science, the method I use when selecting new compounds to try. This discipline is responsible for the discovery of AndrostAnone, beta-androstAnol (molecule A), and DHEAS. I believe Jasmin from AD also understands the concept of SAR.
--- will revisit & edit to format this thread properly and summarize results ---
General Discussion:
This compound was of interest to me due to it's similarity to pregnenolone, which seems to have some moderate pheromone potency. This is the potassium sulfate salt of Pregnenolone. The difference between the alkali metal (potassium or sodium) in the compound seems to make little difference.
It seems as if sulfated derivatives of known pheromones can have some interesting behavior. The addition of the sulfate molecule to the 3rd carbon in A-ring (3-sulfate instead of 3-hydroxy) produces unpredictable changes that cannot be theorized before actual experience. Sometimes, the sulfated pheromones produce better effects, as in the case of sulfating DHEA to obtain DHEAS.
I was hoping Pregnenolone would follow the same structure-activity logic as DHEA is to DHEAS. No such luck here it seems.
Interestingly, the solution of this compound in alcohol has turned a pinkish hue after sitting in the lab fridge for several months.
P.S. To learn more about structure activity relationships, please visit this link. This is the backbone science, the method I use when selecting new compounds to try. This discipline is responsible for the discovery of AndrostAnone, beta-androstAnol (molecule A), and DHEAS. I believe Jasmin from AD also understands the concept of SAR.