Quote:The plant "DAMIANA" contains "β-Sitosterol"
CAS# 84-46-5
Synonyms:
22,23-Dihydrostigmasterol,
Stigmast-5-en-3-ol,
β-Sitosterin


β-Sitosterol is widely distributed in the plant kingdom and found in Nigella sativa, pecans, Serenoa repens (saw palmetto), avocados, Cucurbita pepo (pumpkin seed), Pygeum africanum, cashew fruit, rice bran, wheat germ, corn oils, soybeans, sea-buckthorn, wolfberries, and Wrightia tinctoria.

Quote:
BIOCHANIN A;
5,7-dihydroxy-3-(4-methoxyphenyl)-4h-1-benzopyran-4-on;
5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-Benzopyran-4-one;
APIGENIN 4-METHYL ETHER;
5,7-DIHYDROXY-4'-METHOXYISOFLAVONE;
5,7-DIHYDROXY-4-METHOXYISOFLAVONE;
Genistein 4"²-methyl ether ;
5,7-dihydroxy-3-p-methoxyphenyl-4H-chromen-4-one

Quote:Mechanism of Action:
It is the sex trigger for women's use without color and scent and could easily dissolves in water, drink or alcohol. In a few minutes after taking, women would have itchy feeling in their vagina and would feel tingle on the inside of leg with hurried heartbeat and more and more private parts secretion.

Quote:Duke also recommends that women seeking to boost their sex drive and receptiveness to touch embrace dong quai, damiana, epimedium, fenugreek, ginger, and ginseng, "and that most "˜yin' herb of folklore, wild yam". Duke, who formulated the blend, calls it "Frigiditea". His new book The Green Pharmacy Anti-Aging Prescriptions"”Herbs, Foods, and Natural Formulas To Keep You Young

(08-01-2012 8:52 PM)wiserd Wrote:  I tried yohimbe a while back as a pheromone and got no results. But that was a very early attempt and I looked mainly for self effects. Perhaps I didn't dilute it enough and that over-wrote the signal the way that too high of a dose can. Of course, I got no results taking the stuff orally either, so I could just be immune to it, personally. Or maybe I got a bad batch of the stuff. It'd be good to test on others who have benefited from taking the stuff orally. People who are personally immune to alpha androstenol seem less likely to get social benefits from it as well.

Quote:Yohimbine Hypochloride
(not Yohimbe, but it comes from yohimbe, like 6% of yohimbe is Yohimbine Hypochloride, the other 94% is other stuff)

(08-03-2012 1:50 AM)wiserd Wrote:  

Finasteride


Testosterone

Edti: You know, thinking it through and I really can't guess what the pheromonal effect of finesteride or beta sitosterol will be based on the systemic effect since I doubt much of the stuff will reach the scalp which seems to be beta sitosterol's primary target (or scalp and prostate for finesteride.)

Quote:Female Free Testosterone, pg/mL
18-30 years: 0.8-7.4 pg/mL
31-40 years: 1.3-9.2 pg/mL(.000,000,000,001,300 - .000,000,000,009,200g/mL or .0052-.0552mcg in 4-6L of blood)

41-51 years: 1.1-5.8 pg/mL

Serum Total Testosterone Female, ng/dL
14-15 years: 6-52 ng/dL
16-17 years: 9-58 ng/dL
18-39 years: 9-55 ng/dL(.000,000,000,090 - .000,000,550g/mL or .36-2.2mcg in 4-6L of blood)
40-59 years: 9-55 ng/dL
60 years and older: 5-32 ng/dL

Male Free Testosterone, pg/mL
12-13 years: 0.5-98.0 pg/mL
14-15 years: 3-138.0 pg/mL
16-17 years: 38.0-173.0 pg/mL
18 years and older: 47-244 pg/mL(.000,000,000,047 - .000,000,000,244g/mL or .188-1.464mcg in 4-6L of blood)

Serum Total Testosterone Male, ng/dL
12-13 years: 3-619 ng/dL
14-15 years: 31-733 ng/dL
16-17 years: 158-826 ng/dL
18-39 years: 300-1080 ng/dL (.000,000,003 - .000,001,080g/mL or 12-18mcg in 4-6L of blood)
40-59 years: 300-890 ng/dL
60 years and older: 300-720 ng/dL
http://www.aruplab.com/guides/ug/tests/0081056.jsp

Quote:Several studies have shown the influence of the oestrous cycle on anxiety levels and the important role of progesterone in this effect. The metabolism of this steroid hormone yields neuroactive steroids among them allopregnanolone (alloP) and allotetrahydrodeoxycorticosterone (alloTHDOC), which bind to GABAA receptors and have anxiolytic effects. Considering that during pregnancy there is an increase in levels of both progesterone and its metabolites, the main objectives of this work were: (1) to assess changes in anxiety levels during pregnancy and (2) to verify the role of alloP and alloTHDOC in this process using finasteride, an inhibitor of 5alpha-reductase, the enzyme responsible for their synthesis. The results showed a significant reduction in anxiety levels on the 19th day of pregnancy, which was reversed by finasteride, suggesting a role for alloP and alloTHDOC in the anxiolytic process.

http://www.ncbi.nlm.nih.gov/pubmed/17156832

(10-07-2012 10:19 PM)wiserd Wrote:  This suggests that beta sitosterol might increase anxiety. It's a long shot since it exerts its effects in the body primarily by inhibiting an enzyme (5-alpha reductase) rather than activating or blocking a receptor. If it DID work pheromonally, that would say a LOT about the mechanism by which pheromones worked.

(11-02-2012 4:37 PM)dexter Wrote:  Hmm,
I never got anyone to bite on the reason I started this thread.

The Putatives from Androtics come mixed with Plant Sterols to "AID DIFFUSION".

I look at the term "AID DIFFUSION" and saw something else.
I saw a problem, if these Plant Sterols, such as above, are naturally occuring aphrodisiacs, there may be some mix up in the results of the Pxxx Putatives that contain them. Since the putatives contain sterols, the effects that are seen may be from the putatives, or a combo of the putatives and Molecule, rather than pure effects of a single molecule.

The other thing I saw, reading between the lines, was that these Plant Sterols were used for disguise. They are so close in molecular structure to many pheromones/hormones/steroids/sterols that it would make detection harder. You can't reverse engineer a putative if it has 5 molecules in it that appear so similar in molecular structure. It would be like making a suicide at the soda fountain (mixing a squirt of every flavor of soda) and then asking someone to take a sip and tell you what type of soda it was.

So, there is nothing wrong with a company adding 10mg of plant sterols along with 1mg of actual putative molecule into 30mL and calling it a putative. Especially when it is also adding 6% fragrance (6% of 30mL is about 1.8mL, around 1800mg of fragrance) per 1mg of putative. Just to clear up my numbers, 1mg of putative molecule will make 5mcg/spray out of 30mL, if you get 200 sprays out of the 30mL.

What would be wrong would be to contribute the effects of the putative to the putative molecule without giving credit to the plant sterols, which are considered to be aphrodisiac scents over the decades and centuries. This could be considered aliasing results, coupled results, or cross coupled results. All of which we experience without this added layer of mixing, just because 'mones are that complicated, especially in mixes.

So...
will anyone bite on this now?

(11-02-2012 4:37 PM)dexter Wrote:  Hmm,
I never got anyone to bite on the reason I started this thread.

The Putatives from Androtics come mixed with Plant Sterols to "AID DIFFUSION".

I look at the term "AID DIFFUSION" and saw something else.
I saw a problem, if these Plant Sterols, such as above, are naturally occuring aphrodisiacs, there may be some mix up in the results of the Pxxx Putatives that contain them. Since the putatives contain sterols, the effects that are seen may be from the putatives, or a combo of the putatives and Molecule, rather than pure effects of a single molecule.

The other thing I saw, reading between the lines, was that these Plant Sterols were used for disguise. They are so close in molecular structure to many pheromones/hormones/steroids/sterols that it would make detection harder. You can't reverse engineer a putative if it has 5 molecules in it that appear so similar in molecular structure. It would be like making a suicide at the soda fountain (mixing a squirt of every flavor of soda) and then asking someone to take a sip and tell you what type of soda it was.

So, there is nothing wrong with a company adding 10mg of plant sterols along with 1mg of actual putative molecule into 30mL and calling it a putative. Especially when it is also adding 6% fragrance (6% of 30mL is about 1.8mL, around 1800mg of fragrance) per 1mg of putative. Just to clear up my numbers, 1mg of putative molecule will make 5mcg/spray out of 30mL, if you get 200 sprays out of the 30mL.

What would be wrong would be to contribute the effects of the putative to the putative molecule without giving credit to the plant sterols, which are considered to be aphrodisiac scents over the decades and centuries. This could be considered aliasing results, coupled results, or cross coupled results. All of which we experience without this added layer of mixing, just because 'mones are that complicated, especially in mixes.

So...
will anyone bite on this now?

(11-02-2012 4:50 PM)wiserd Wrote:  Interesting notion. What's a bite? Testing plant sterols? There's a lot of promise there but its hard to get testers for anything.

(11-08-2012 6:25 PM)dexter Wrote:  Oh. What's a bite. Well when you fish, you put bait on a hook, throw it in the water, and hope for a fish to take hold of it, only fish don't have hands, only mouths, so they bite. They bite on the bait.

I was throwing out some bait on the topic of Androtics putatives containing plant sterols.

And looking to see if anyone else felt as I did; that the Androtics putatives being advertised as a single putative molecule combined with plant sterols and scent were actually mixes of putatives, the plant sterols being putatives in addition to the "single" molecule.

reading between the lines, i meant to say, If an androtics molecule has plant sterols in it in addition to the putative molecule, it is possible that you are getting pheromone reactions to the plant sterol alone, and no real reaction to the putative molecule.

Because the plant sterols listed in this thread have years of history as "aphrodisiacs", as scents and as foods, and they look similar to existing pheromones in there chemical structure.

(11-09-2012 12:56 AM)Grape Ape Wrote:  Couldn't these plant sterols be the putative?


On another note: Finesteride might as well be looked at as poison for the male body. It has ruined many lives, and there are plenty of class action suites. I'd advise one to do their homework before researching with it in any way.

(11-08-2012 10:42 PM)wiserd Wrote:  *laughs*
Reminds me of Airplane, the movie.
"You'd better tell the Captain we've got to land as soon as we can. This woman has to be gotten to a hospital."
"A hospital? What is it?"
"It's a big building with patients, but that's not important right now."
I just was asking what you wanted from us. ;-)

(11-08-2012 10:42 PM)wiserd Wrote:  I wasn't able to get a noticable reaction with yohimbe. But maybe there was something wrong with my extract. Were you?

(11-08-2012 10:42 PM)wiserd Wrote:  tongkat ali
cucumber seed extract
Magnolia extract
Glycyrrhizic acid

(11-08-2012 10:42 PM)wiserd Wrote:  You could very well be right about Androtics. It's hard sometimes to tell if the folks at Androtics are confused or just being deliberately obfuscatory and trying to confuse others. But personally I have enough toys that I'm not too worried about reverse engineering their stuff any more. I'm sure that there are a ton of active plant sterols. It's just a matter of diving in and testing them.

Pure speculation isn't going to inspire people. We have a lot of it around here. If you get a positive report, though, you can call in the cavalry.

Quote:http://www.drugs.ie/resourcesfiles/guides/Psychoactive_substances_low_res.pdf

Clary Sage (Salvia sclarea)
Common Names: Clary, Clary Wort, Clear Eye, Eyebright, Muscatel Sage, See Bright

Classification: Sedative
Classification: Narcotic, Pain Reliever
Classification: Stimulant

Method of Use: Smoke.

Drug Effects: The mucilaginous seeds are used to clear eyes, the leaves are used to flavour wine. This sage is used extensively in perfumes as a fixative and fragrance. Clary is the scent of "Euphoria".

Short Term Effects: Pick me up, mild euphoria, similar to THC.

Long Term Effects: Antibacterial, anticonvulsant, anti-diarrhoeal, Antispasmodic, astringent, carminative, emmenagogue, tonic.

Negative/Overdose Risk: Heartburn.

Active Constituents: 1,8-Cineol, Alpha-Bisabolol, Alpha-Pinene, Alpha-Terpineol, Alpha-Terpinyl-Acetate, Arachidic-Acid, Benzaldehyde, Beta-Caryophyllene, Beta-Gurjuene, Beta-Myrcene, Camphor,
Caprylic-Acid, Caryophyllene-Oxide, Cerotinic-Acid, Cis-3-Hexen-1-Ol, Cis-Allo-Ocimene, Cis-Beta-Ocimene, Cis-Linalol-Oxide, Citral, Citronellol, Cuminaldehyde, Delta-3-Carene, Furfurol, Geraniol, Geranyl-Acetate, Isospathulenol, Lignoceric-Acid, Limonene, Linalol, Linalyl-Acetate, Manool,
Myrcene, N-Nonanol, N-Pentanol, Nerol, Neryl-Acetate, Oleanolic-Acid, P-Cymene, Phytosterols, Propionic-Acid-Ester, Protein, Rosmarinic-Acid, Salvia-4(14)-En-1-One, Sclareol, Stearic-Acid, Tannin, Terpinen-4-Ol, Trans-Beta-Ocimene, Trans-Beta-Terpineol, Trans-Linalol-Oxide, Ursolic Acid, Valeric-Acid-Ester.

Contraindications / Interactions: Should not be used in pregnancy due to its emmenagogue properties. Interacts with chloral hydrate, hexobarbitone.

Psychoactive Ingredient In: Diablo, Iced Diamond, Turbo III Rave.

Legality: Contains no controlled substances

(11-20-2012 3:50 AM)Mara ~ Love Potion Wrote:  I apologize for intruding, but just FYI - this is the entire basis behind Love Potion fragrances. We have been blending plant, animalic and even insect derived scents for well over 25 years without pheromones, but with pheromonal effects. If you are interested in the kinds of effects you might achieve without Pheromones, or to boost and compliment your phero results, you might consider checking us out.

We have a program called Private Editions. We can make you a blend of your own design for less $$$ than it would cost you to buy a bunch of individual ingredients yourself, and of course we will blend it for you in proper measure. This service takes around 2-3 weeks.

http://www.lovepotionperfume.com/store/Private_Editions.html
Second item down on the page. If the ingredient you want is not listed, just write it in, in the space provided. We will email you if we don't have it, but chances are, we do. We have tens of thousands of essences here to choose from.

Mark - just delete this post if it is not appropriate.

(11-21-2012 12:41 PM)Mara ~ Love Potion Wrote:  Wiserd, we are completely open about the effects of ingredients! Each perfume offering has a list of the majority of their ingredients and their most typical responses that they invoke. (These are one line light-hearted summaries for the sake of people's patience; you could go on for pages about the properties of each ingredient.)

Here's a copy/paste of the listing for Pashazade for example - one of our popular men's blends:

Magickal Meanings of Ingredients:

ROASTED TEA LEAVES ~ Invigorating, refreshing, mentally and physically uplifting, lust. Riches, courage, strength.
WHITE CEDAR ~ Confidence inducing, balancing, grounding, energizing, money, healing, protection, purification
BERGAMOT ~ Relaxant, confidence builder. Uplifts emotions, protection, attracts riches. Mental alertness, energizing.
AMBER ~ Fertility, creativity, love, luck, riches.
MUSK ~ Self confidence and strength, sexual attractant, heightens passions and arousal.
MYRRH ~ Stimulating, soothing. Powerful guard against evil.
GINGER ~ Fiery and fortifying, induces passion. Intensifies love spells and success spells. Love, money, success, power. Ginger increases sensitivity in the erogenous zones.
CARAWAY ~ Passion, lust, protection, health, mental prowess.
CINNAMON ~ Male sexual stimulation, passion, lust, healing, protection, energy, creativity, psychic powers.
CLOVE ~ Money attracting, deflects negative and hostile energies.

The "meanings" of the ingredients that we post come from a variety of sources - the list is an amalgamation and since we have a whimsical magical approach much of it is presented in that way rather than scientific-style, or "health benefits" style which is technically not legal. Some are known responses to specific stimuli that go back centuries. Some are derived from religious traditions, and some are from folklore from cultures the world over.

Here's our master list, posted in our Reading Room area:
http://lovepotionperfume.com/reading_room/lore/ingredient_lore

To answer your questions, (and please forgive that I do not have your wonderfully scientific vocabulary):
I have tens of thousands of ingredients here, amassed over decades, some of the most expensive rare oils on earth. I do not like or use straight aldehydes. I bought a handful of them a couple of years ago out of curiosity and most of them give me an instant blazing headache. They are linear, compressed smelling, chemical smelling. However, it is not possible, as you know, to get your hands on natural ingredients 100% of the time, (nor would you even want to as your palette would be incredibly limited if you did) - many are now illegal or ecologically irresponsible, some are cost prohibitive, and many plants when processed into oils smell completely different...such as the flower smells one way, but the derivative of the flower simply smells like camphor. So in making the perfect pear scent for example, you have to use a mix of natural and artificial oils, different fruits and florals, and then you finally get to pear. In my experience, it is not necessary for oils to be 100% plant derived/natural in order to produce the known/desired response. The PERCEPTION of pear to those that smell it is more important than the ingredients you used to get there.

Of our senses, smell is our strongest. Sound is second, and sight is actually third. Aromas can produce an instant sense memory - blast a person right back to the time and place they smelled it before, even after many decades....just like hearing a song from your youth can take you right back to the time and place you first heard it. Our sense of smell is directly attached to our limbic system, pituitary and hypothalamus area, the oldest and most primitive parts of our brains which control memory and the release of hormones that directly affect our emotions, sensual/sexual responses, nervous system, stress levels, concentration, etc. As such, if you know what you are doing, you can quite easily manipulate/steer/encourage/evoke specific responses in people by exposing them to smells. Of course, their personal experiences will skew the results, so you're not guaranteed the same response from every person, but an extremely powerful tool to have nevertheless.

Let's take vanilla for example. Vanilla is the most used fragrance ingredient in the world for a reason, and from what I have read and experienced, evokes genuine pheromonal responses. Why is this? Mother's milk has a somewhat vanilla flavoring to it; so subconsciously, the smell of vanilla will evoke feelings of loving safety and nurturing, as well as oral fixation and a yearning for cuddling at the breast. For many, the scent of vanilla brings to the fore treasured childhood memories of baking mouth-watering cookies in a warm kitchen with a parent or grandparent. While women tend to love vanilla as well, it's especially effective when worn by women to entice men. I figured out at age 14 that dabbing vanilla extract in the area of the cleavage evokes oral fixation in men, they want to devour the gal that is wearing it...but also it makes men feel safe. The girl who smells like natural vanilla is the kind you want to incorporate into your family - you can bring her home to mother and nest with her and have babies with her. It's mood elevating and makes you feel snugly, and in adults, quite frisky as well.

Regarding musks, there's a HUGE range of musks out there, from the soapy-clean to the dirty animalic. My musk collection probably includes over 300 different types. There is a plant seed, ambrette, which smells like deer musk...it's still natural, but not animal derived. If you're willing to spend the time and the money, you can still stumble across natural animal musks for sale here and there that are older than the prohibition against them. (This is still illegal to trade, btw, but it's out there.) Animal musks, ambergris (whale musk), and most resins improve with age. They get deeper and thicker, richer and more potent as time goes by, so a tiny tiny drop of an aged ingredient like this is all you may need for a gallon of perfume. When you are playing with musks, you first have to decide what your goals are. When a musk is described as "animalic" we are generally talking dirty smelling. They smell vaguely like urine. If blended properly with other ingredients, the dirty smell comes off smelling very very sexy. Unwashed maybe, or like you've just had sex. It can be wildly arousing to people. However, there's the type of people who only like clean freshly showered smells and are turned off or frightened by the aroma of dirty sex, so luckily there are other musks, perhaps more like human semen which I have heard described by some men as smelling "bleach-like", and these are soapy clean smelling or vaguely flowery. A clean smelling musk can also be extremely effective for a man to wear for business purposes. It presents the male as virile and powerful, yet clean and professional.

When I am talking about insect scents, I mean honey and bee pollen. Again, there are hundreds of honey types and honey absolutely produces pheromonal responses in people. Bees are pheromone controlled creatures, and I'm sure that the honey and pollen derived oils are filled with insect pheromones. Some honeys are very dark and civit-like, and can easily be used as substitution for civit musk. There's also a plant hormone I use, (that one I cannot tell you the name of but you might be able to figure it out) the purpose of the plant hormone is to attract bees etc to pollinate the plants and spread the species. In great concentration, this plant hormone smells like civit. In light concentration, it's a gorgeous honey smell.

Ack, I think I have been too long winded for now. But please feel free to ask anything you like and I will answer as best I can.

(11-20-2012 3:50 AM)Mara ~ Love Potion Wrote:  I apologize for intruding, but just FYI - this is the entire basis behind Love Potion fragrances. We have been blending plant, animalic and even insect derived scents for well over 25 years without pheromones, but with pheromonal effects.

(08-01-2012 1:55 AM)dexter Wrote:  Yohimbine Hypochloride
(not Yohimbe, but it comes from yohimbe, like 6% of yohimbe is Yohimbine Hypochloride, the other 94% is other stuff)

(11-09-2012 12:56 AM)Grape Ape Wrote:  Couldn't these plant sterols be the putative?


On another note: Finesteride might as well be looked at as poison for the male body. It has ruined many lives, and there are plenty of class action suites. I'd advise one to do their homework before researching with it in any way.

(12-16-2014 7:56 PM)dexter Wrote:  I'd like to throw Nutmeg onto the list too. Maybe not as a sterol, but as a plant based putative pheromone.

(01-02-2015 11:38 AM)DrHorrible Wrote:  It seems there are false connections being made between biological (in vivo) effects and pheromonal effects of chemicals.

(01-02-2015 11:38 AM)DrHorrible Wrote:  if you look at the most scientifically tested and proven human pheromones, at least the steroid ones, you'll find that these are the LEAST effective hormones in the body.

(01-02-2015 11:38 AM)DrHorrible Wrote:  The explanation for this is a simple evolutionary one.

(01-02-2015 11:38 AM)DrHorrible Wrote:  Real clues for pheromonal activity will likely come from theories of olfaction, assuming that olfaction and pheromone detection are similar.

(01-02-2015 11:38 AM)DrHorrible Wrote:  These are very likely not the same receptors that are responsible for hormone and drug action.

(01-02-2015 11:38 AM)DrHorrible Wrote:  These effects of a single molecule are almost more likely to be opposite than similar.

(01-02-2015 11:38 AM)DrHorrible Wrote:  Since this thread was revived, and I went through and read the whole thing, I just wanted to add something. It seems there are false connections being made between biological (in vivo) effects and pheromonal effects of chemicals. A common theme is the conjecture that if XXX promotes Z effect in the body, it should be tested for similar results as a pheromone. However, if you look at the most scientifically tested and proven human pheromones, at least the steroid ones, you'll find that these are the LEAST effective hormones in the body. The explanation for this is a simple evolutionary one. Sex steroids are metabolized (deactivated) by the body and excreted in sweat. Humans (among other animals) evolved a way to sense the presence of these sex hormone metabolites, which hint at the levels and balance of the hormones inside the body.

Real clues for pheromonal activity will likely come from theories of olfaction, assuming that olfaction and pheromone detection are similar. Receptor binding will likely explain most, but "vibrational" theory may have a role, too. These are very likely not the same receptors that are responsible for hormone and drug action. Either way, the molecular shapes (including conformers) and electron density will eventually predict pheromone activity, but just because we don't have that information now doesn't mean we should be connecting biological effects with the pheromonal. These effects of a single molecule are almost more likely to be opposite than similar.

Quote:https://www.ncbi.nlm.nih.gov/pubmed/20570588
Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration.
----
Abstract

Neurosteroids hold great promise for the treatment of diseases of the central nervous system (CNS). We compared the uptake by 11 brain regions and appearance in blood of tritium-labeled pregnenolone and progesterone after intranasal and intravenous (IV) injection. Both neurosteroids appeared in blood and brain after either method of administration, but with important differences in uptake. Bioavailability based on appearance in arterial serum showed that about 23% and 14% of the intranasal administered doses of pregnenolone and progesterone, respectively, entered the blood. Brain levels were about two fold lower after intranasal administration for the two neurosteroids. With intranasal administration, brain levels of the two steroids did not vary over time (2-120 min), whereas brain levels were higher early (10 min or less) after i.v. administration. With i.v. administration, uptake by brain regions did not vary, whereas the olfactory bulb, hippocampus, and hypothalamus had high uptake rates after intranasal administration. Intranasal administration of prenenolone improved memory, whereas progesterone decreased anxiety, thus demonstrating that therapeutic levels of neurosteroids can be delivered to the brain by intranasal administration. The neurosteroids were rapidly degraded after i.v. or intranasal delivery, but pregnenolone was more resistant to degradation in the brain after intranasal administration and in serum after i.v. administration. These results show that either the i.v. or intranasal routes of administration can deliver neurosteroids to blood and brain, but that the two routes have significant differences with intranasal administration favoring some brain regions.

(02-08-2017 6:05 PM)dexter Wrote:  In response to what Dr. Horrible wrote and Paradox bumped:

With this info.....
knowing that 24% showed up in the blood during this study....
A person could DOUBLE their blood concentration by inhaling between 2mcg-40mcg of Pregnenolone!

There would also be a significant amount of the molecule that does not go to the blood, but goes to the brain. Both effects can be had simultaneously by inhaling the 'mones.

(02-09-2017 4:25 AM)GoergeFocky Wrote:  So, discussing these things openly is a two-edged sword for the phero-scene, to put it mildly.

(02-08-2017 6:05 PM)dexter Wrote:  A person could DOUBLE their blood concentration by inhaling between 2mcg-40mcg of Pregnenolone!

(02-09-2017 11:29 PM)metaltree Wrote:  I do not think they mean "inhaling" when they wrote about intranasal administration. I think they meant absorbing the steroid through the mucus membranes inside a person's nasal structures.

(02-10-2017 5:19 AM)GoergeFocky Wrote:  To come back to the purpose of the thread with these things in mind:

I wonder how Methyl-Salicylate behaves after inhalation. Brain Inflammation is associated with so many affective and neurological disorders that an anti-inflammatory (salicic acid) agent directly effective in the hypothalamus and hippocampus would seem promising. Methyl-Salicylate is a lipophilic volatile, so it might easily enter the brain. But what with the methyl-group there?

Quote:Prostaglandin E2 stimulates estradiol synthesis in the cerebellum postnatally with associated effects on Purkinje neuron dendritic arbor and electrophysiological properties.

Treatment with cyclooxygenase inhibitors reduced cerebellar aromatase activity ... These findings reveal a previously unappreciated role for PG-stimulated steroidogenesis in the developing brain and a new potential route for inflammation-mediated disruption of neuronal maturation.

(02-09-2017 11:29 PM)metaltree Wrote:  I do not think they mean "inhaling" when they wrote about intranasal administration. I think they meant absorbing the steroid through the mucus membranes inside a person's nasal structures.

Quote:Absorption of Toxicants.
http://www.olemiss.edu/courses/phcl675/gentox2.pdf
Penetration and absorption of gases and vapors into the lungs:
gases and vapors come into equilibrium with blood in the alveolar capillaries almost instantaneously. This reflects Dalton's law of partial pressures, Henry's law (solubility of gases over a liquid), and the gases lipidaqueous partition coefficient.

Absorption of Aerosols by the lung
nonlipid soluble compounds the rate of absorption varies inversely with molecular size. Lipophilic aerosols pass epithelium rapidly. Also energy dependent transport systems in Type I and II alveolar cells.