I dont know about run down. I remember after using it for a week i felt bouts of irritability. Made me wonder if it had beta doc in it. I dont recall feeling this the first couple of days but after a while i would feel irritated and more easily annoyed. I tend to go heavy with the application. 3-4 drops when i apply.

I looked into ATJ as a possible replacement for 297 and i do feel run down a few hours after using just 297. I never noticed that run down feeling until i stopped using IS with 297 and just used it as a standalone.

If it does have beta doc in it i wonder if the mcg threshold that diane talks about can change with repeated use.