I've read tons over at Longecity, so I'm certainly aware of choline overload. As far as I'm aware, Coluracetam upregulates the choline system rather than depleting it, so I'm fairly certain this isn't the case here. This felt more like the headache from IDRA amplified - something seemed to be interacting here, though I'm not sure what. I'm an enthusiast after all, not a scientist.

I wouldn't say herbals are necessarily safer than most racetams (especially the more researched 4, Ani, Oxi, Pira, and Colur). Keep in my that Turmeric contains an MAOI as an active ingredient and that Rhodiola and Kava are MAOIs themselves and should not be combined under any circumstances. Just because something is natural doesn't make it safe. Always be aware of side effects and potential interactions, as some can be fatal. Outside of Deprenyl, I tend to steer clear of MAOIs for this very reason.

(12-10-2013 5:23 AM)Ekscentra Wrote:  I've read tons over at Longecity, so I'm certainly aware of choline overload. As far as I'm aware, Coluracetam upregulates the choline system rather than depleting it, so I'm fairly certain this isn't the case here. This felt more like the headache from IDRA amplified - something seemed to be interacting here, though I'm not sure what. I'm an enthusiast after all, not a scientist.

I wouldn't say herbals are necessarily safer than most racetams (especially the more researched 4, Ani, Oxi, Pira, and Colur). Keep in my that Turmeric contains an MAOI as an active ingredient and that Rhodiola and Kava are MAOIs themselves and should not be combined under any circumstances. Just because something is natural doesn't make it safe. Always be aware of side effects and potential interactions, as some can be fatal. Outside of Deprenyl, I tend to steer clear of MAOIs for this very reason.

Thanks I was not aware that Kava was an MAOI, even though it is a weak one. The hazards of interactions with medications and synthetics is much more serious than naturally occurring substances with reversible MAOI activity (Rhodiola, Curcumin/Turmeric, Kava). They seem to get mixed up especially in warnings against tyramine containing foods and beverages. Reversible inhibitors is much safer and you have to really dig around to find a case of serotonin syndrome from herbs alone, I have yet to see one. The most common case of SS is mixing SSRI's with MAOIs or mixing MDMA with MAOIs. There are people taking Rhodiola while on SSRIs, even though it is not recommended it is not a problem normally. People get this all mixed up when it comes to reversible inhibitors. It's the irreversible ones you wanna stay away from, which most are 'man made'.

Just took ~100mg IDRA orally this morning. No effects noticed as of yet other than the pressure in my head, which seems no greater than in lower doses. Will report back if I notice anything of interest.

Visualization seems noticably (but not significantly) greater compared to baseline. The subtle effects experienced the first day must have been placebo. Muscle memory is significantly more consistent while on IDRA, the only reason this experiment hasn't been a complete disappointment. I'll be switching back to PRL and adding Coluracetam, Deprenyl, and occasional Galantamine.

As far as PRL, I've noticed a subtle increase in memory retention, but again, no other effects.

Took ~8mg of PRL with ~24mg Coluracetam yesterday. The first and only pronounced effect from the combo happened when writing an essay. I found my flow to be far greater than usual, and while my word choice wasn't entirely unusual for myself, the ordering made my writing seem very elegant. I had a bit more of an "artsy"style than usual, preferring to be less blunt and matter-of-fact about things. Style over substance, but in a good way. I didn't notice the usual subtle effect PRL has on my memory retention, but I really had nothing I needed to memorize that day either. It seems these 2 really only shine when you push yourself, something I'm rarely able to do with all the problems I'm currently facing (remnants of drug-induced depression, issues in the PFC due to ADD, unwilling to treat the symptoms due to all the horrendous substances I'd been prescribed, insomnia, mental fatigue possibly due to sleep apnea, etc.) It'll take a good bit of work, but I'm determined to rid myself of every last one of these issues. As I cling on to this one and only life, the promise these new substances bring are all that's motivating my will to live. I'll attempt to have my doctor prescribe Memantine, Intuniv, and Armodafinil once I have time to pay him a visit. Deprenyl and Galantamine are the next two I plan to try, and possibly NSI-189 within these next couple of months, which by the way just became available through a reputable eBay seller named nyles7. Hopefully the product is of acceptable purity, else I may just wait for the next group buy on Longecity. I'll update if anything interesting occurs.

IDRA just triggered some of the most self-destructive thought patterns I've yet experienced on a substance. No amphetamine could trigger such strong hatred in me. No SSRI has made me so careless towards others. I now understand a report on Reddit describing this as the most terrifying substance he's ever ingested - I now understand what he means. After less than 10 doses, never again will I take this poisonous drug. Much longer and I fear that I'd go insane. I now understand why Isochroma recommended suicide for another user at Longecity. Just sitting here, I fear I might've taken the same path. Suicide is once again in the back of my mind. I only hope I survive the half-life of this drug - my last dose was yesterday, so I have another 2 days before the effects die down. Seriously dangerous stuff, guys. This is not a nootropic, this is a drug that slowly convinces you to commit suicide. Heroin feels relatively safe after experiencing the dark side of IDRA. Avoid at all costs.

(01-01-2014 3:14 AM)Ekscentra Wrote:  IDRA just triggered some of the most self-destructive thought patterns I've yet experienced on a substance. No amphetamine could trigger such strong hatred in me. No SSRI has made me so careless towards others. I now understand a report on Reddit describing this as the most terrifying substance he's ever ingested - I now understand what he means. After less than 10 doses, never again will I take this poisonous drug. Much longer and I fear that I'd go insane. I now understand why Isochroma recommended suicide for another user at Longecity. Just sitting here, I fear I might've taken the same path. Suicide is once again in the back of my mind. I only hope I survive the half-life of this drug - my last dose was yesterday, so I have another 2 days before the effects die down. Seriously dangerous stuff, guys. This is not a nootropic, this is a drug that slowly convinces you to commit suicide. Heroin feels relatively safe after experiencing the dark side of IDRA. Avoid at all costs.

Sounds nasty man, hang in there it will pass! I've experienced similar stuff on RCs, it sucks and the reason why I stay away. Get out and do something you usually like to distract you while the effects die down.

Fortunately the effects subsided after taking a nap for a few hours. Past emotional trauma in combination with IDRA's emotional amplification caused a mild state of psychosis/mania. Looking back at what I had written in this state brings to mind Isochroma in his hypomanic days, though much more self-destructive. The few benefits I've received from IDRA simply aren't worth all the nasty sides. I'll stick to PRL + Colur for now, though this won't deter me from continuing to try the latest substances. I'll just have to be a little more careful from here on out. Just because something is labeled as a nootropic doesn't mean it can't kill you, and this is the worst of 'em at the moment.

I swear by modafinil but I've also had good results with phenibut. Moderation and control is very important with these two though, especially the latter.

Talking about modafinil, anybody know where I can order some to Canada without an prescription?