I was looking at the internet. It just sat there, didn't do much.

this article got me thinking about Plant Sterols as Aphrodisiacs. Mostly because the article was about Plant Sterols acting as Aphrodisiacs in humans.

Have I got an herb for you!
Aphrodisiacs have been used worldwide since the dawn of human history. Researchers are just beginning to discover their chemical and physiological functions.
http://pubs.acs.org/subscribe/archive/ci...wartz.html

Quote:The plant "DAMIANA" contains "β-Sitosterol"
CAS# 84-46-5
Synonyms:
22,23-Dihydrostigmasterol,
Stigmast-5-en-3-ol,
β-Sitosterin


β-Sitosterol is widely distributed in the plant kingdom and found in Nigella sativa, pecans, Serenoa repens (saw palmetto), avocados, Cucurbita pepo (pumpkin seed), Pygeum africanum, cashew fruit, rice bran, wheat germ, corn oils, soybeans, sea-buckthorn, wolfberries, and Wrightia tinctoria.

But there was a molecule:
CAS# 491-80-5
Biochanin A
synonyms:

Quote:
BIOCHANIN A;
5,7-dihydroxy-3-(4-methoxyphenyl)-4h-1-benzopyran-4-on;
5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-Benzopyran-4-one;
APIGENIN 4-METHYL ETHER;
5,7-DIHYDROXY-4'-METHOXYISOFLAVONE;
5,7-DIHYDROXY-4-METHOXYISOFLAVONE;
Genistein 4′-methyl ether ;
5,7-dihydroxy-3-p-methoxyphenyl-4H-chromen-4-one

Biochanin A comes from RED CLOVER PLANT

Also had a "Spanish Fly" type description of:

Quote:Mechanism of Action:
It is the sex trigger for women’s use without color and scent and could easily dissolves in water, drink or alcohol. In a few minutes after taking, women would have itchy feeling in their vagina and would feel tingle on the inside of leg with hurried heartbeat and more and more private parts secretion.

Yohimbine Hypochloride
(not Yohimbe, but it comes from yohimbe, like 6% of yohimbe is Yohimbine Hypochloride, the other 94% is other stuff)


muira puama (Ptychopetalum olacoides), also known as “erection root”

Quote:Duke also recommends that women seeking to boost their sex drive and receptiveness to touch embrace dong quai, damiana, epimedium, fenugreek, ginger, and ginseng, “and that most ‘yin’ herb of folklore, wild yam”. Duke, who formulated the blend, calls it “Frigiditea”. His new book The Green Pharmacy Anti-Aging Prescriptions—Herbs, Foods, and Natural Formulas To Keep You Young

also, plant sterols that are recommended as human aphrodisiacs:

campesterol (CAS# 474-62-4, Campestanol; (24R)-Ergost-5-en-3β-ol) Banana, pomegranate, pepper, coffee, grapefruit, cucumber, onion, oat, potato, and lemon grass (citronella) are few examples of common sources containing campesterol at ~1-7 mg/100 mg of the edible portion. In contrast canola and corn oil contain as much as 16-100 mg/100mg.



stigmasterol (CAS# 83-48-7, Stigmasterin)


Stigmastanol CAS# 83-45-4,
aka
(3β)-Stigmastan-3-ol;
(3β,5α)-Stigmastan-3-ol;
β-Sitostanol;
Dihydrositosterin;
Dihydrositosterol;
Dihydro-β-sitosterol;
Fucostanol;
Spinastanol;
24α-Ethylcholestanol)
http://www.hmdb.ca/metabolites/HMDB00494


?other stigmastanol CAS#19466-47-8?



ergosterol (provitamin D2)
(ergosta-5,7,22-trien-3β-ol)
It is turned into viosterol by ultraviolet light, and is then converted into ergocalciferol, a form of vitamin D also known as D2

Don't these plant sterols and phytosterols look alot like some of the putative pheromone chemical structures?

It makes me wonder a little. Androtics Direct markets their Commercial Line and Putative PXXX series as using plant sterols to aid in diffusion. But IF they contain some of these plant sterols, could they in effect be saying that by mixing a putitive, with a well known plant sterol that acts as an aphrodisiac steroid, you can better bring out the aphrodisiac effect of the putative.

But what you may really see is, the aphrodisiac effect of the plant sterol, which is an aphrodisiac.

Stupid internet. I read an article, then another, then I put two peices of a puzzle together, then I post them as a coherent thought. This is probably why Androtics Direct erases/moderates my posts on their website sometimes and didn't send a free sample to me in my most recent order from them. I drink the stupid Kool-Aid, and then say, "Hey the blue fruit punch and the red fruit punch taste the same."

My "Blueberry Scent" that I created in May 2012 :

40 drops Damiana essential oil
10 drops Canadian Catnip essential oil (they say the Indian one doesn't work)
10 drops Neroli 5% essential oil

2,5 ml Iso-E Super
4 pellets Lauricidin
About 7 ml Perfumers Alcohol (fill it up)

Put it in a 10 ml spray and let it age a few days

The ladies like it, it lasts forever, smells a bit like blueberries.
Don't know about the effects though, I used it as a coverscent.

Edit : I only did 2 versions of it and it might be tried without the Neroli and with less Iso-E. It might very well have aphrodisiac effects, I just never tried it isolated...

For what it's worth; beta sitosterol is notable for behaving in the body like finesteride/propecia (finesteride is the stuff that is supposed to prevent hair loss.) In short, it prevents testosterone from converting into DHT. DHT is a a powerful androgen which also causes hair loss. (Merck seems to play down the benefits of DHT since they sell a pill which tries to prevent its creation, so be careful of popular sources on this topic.)

I've heard it said (not sure how reliable the information was) that some men's sex drive works off of DHT, some off of T and some off of both. If someone's body relied primarily on DHT, the stuff could kill their sex drive. If their sex drive relied on T, it would boost it. If it relied on both... who knows?

Are there certain instances where you'd WANT to reduce conversion of T to DHT for social reasons? Maybe. I'd be interested to hear that argument. Perhaps, you could cause someone to build up a stockpile of T which would be converted to DHT when the beta sitosterol wore off?

Though given that the primary conversion sites for T -> DHT are the scalp and prostate in men (And beta-sitosterol doesn't seem to even reach the prostate in significant quantities), I don't know if pheromonal effects would even interfere with its activity. I suppose that COULD change things entirely.

This could all be pointless speculation, of course. Let me know if your results say something else. I'm just trying to guess what the effects might be based on the published lit.

I tried yohimbe a while back as a pheromone and got no results. But that was a very early attempt and I looked mainly for self effects. Perhaps I didn't dilute it enough and that over-wrote the signal the way that too high of a dose can. Of course, I got no results taking the stuff orally either, so I could just be immune to it, personally. Or maybe I got a bad batch of the stuff. It'd be good to test on others who have benefited from taking the stuff orally. People who are personally immune to alpha androstenol seem less likely to get social benefits from it as well.



counteracting type I and type II isoforms of 5

Finasteride







Testosterone

Edti: You know, thinking it through and I really can't guess what the pheromonal effect of finesteride or beta sitosterol will be based on the systemic effect since I doubt much of the stuff will reach the scalp which seems to be beta sitosterol's primary target (or scalp and prostate for finesteride.)

11-Beta hydroxysteroid dehydrogenase inhibitors seem to work pheromonally. I'll have to see which tissues produce that. If they're far afield from the brain, perhaps beta-sitosterol will behave like it does in the body.

Is there any market for pheromones which prevent people from behaving sexually or that reduced sex drive? Maybe some women would favor that if they were getting unwanted attention. A sort of "down boy" mone... noone's ever asked for it, though. It would filter out a certain type of guy. The high testosterone types would be most strongly affected. There's an interesting social experiment...

(08-01-2012 9:52 PM)wiserd Wrote:  I tried yohimbe a while back as a pheromone and got no results. But that was a very early attempt and I looked mainly for self effects. Perhaps I didn't dilute it enough and that over-wrote the signal the way that too high of a dose can. Of course, I got no results taking the stuff orally either, so I could just be immune to it, personally. Or maybe I got a bad batch of the stuff. It'd be good to test on others who have benefited from taking the stuff orally. People who are personally immune to alpha androstenol seem less likely to get social benefits from it as well.

wiserd,
the Yohimbe effect you got may have been subdued compared to the effect of Yohimbine Hypochloride, or other ingredients that are naturally in yohimbe may act counter the pheromone effects of Yohimbine Hypochloride, since it it makes up only ~6% of yohimbe.

Quote:Yohimbine Hypochloride
(not Yohimbe, but it comes from yohimbe, like 6% of yohimbe is Yohimbine Hypochloride, the other 94% is other stuff)

[/quote]

(08-03-2012 2:50 AM)wiserd Wrote:  

Finasteride


Testosterone

Edti: You know, thinking it through and I really can't guess what the pheromonal effect of finesteride or beta sitosterol will be based on the systemic effect since I doubt much of the stuff will reach the scalp which seems to be beta sitosterol's primary target (or scalp and prostate for finesteride.)

I have read that Testosterone is very pheromonally active, and acts as an aphrodisiac (joke: combine maniac/dizzy/afro hair do = aphrodisiac)
And that free Testosterone is readily available in saliva, verses SHBG bound Testosterone or Albumin bound testosterone. And if it's in saliva, you are exhaling it every time you breath, so constantly. And since it acts pheromonally, if you got more on your breath/saliva, you may be more attractive and a better kisser.

Testosterone supplements will also raise libido in women. Maybe not to the level of Anabolic Steroid levels that are taken in ~100mg levels, but in much lower levels that are closer to the bodies natural levels.

Female Testosterone serum levels (average of some sort) 250 - 850 pg/mL
Male under 50 years Testosterone serum levels (average of some sort) 2,900 - 12,000 pg/mL
Male over 50 years Testosterone serum levels (average of some sort) 1,800 - 7,500 pg/mL
Male DHT serum levels (average of some sort) 300 - 850 pg/mL

Sex hormone-binding globulin (SHBG): Most testosterone circulating in the bloodstream is bound to either sex hormone-binding globulin (SHBG) (60%) or albumin (38%). Only a small fraction (2%) is unbound, or “free”. (Morales et al 2010).
http://www.lef.org/protocols/male_reprod...ion_01.htm

Hormone Optimal Range
DHEA-s: 350-490 μg/dL
Estradiol: 20-30 pg/mL
Total Testosterone: 700-900 ng/dL (7,000-9,000pg/mL)
Free Testosterone: 20-25 pg/mL
http://www.lef.org/protocols/male_reprod...ion_02.htm

Quote:Female Free Testosterone, pg/mL
18-30 years: 0.8-7.4 pg/mL
31-40 years: 1.3-9.2 pg/mL(.000,000,000,001,300 - .000,000,000,009,200g/mL or .0052-.0552mcg in 4-6L of blood)

41-51 years: 1.1-5.8 pg/mL

Serum Total Testosterone Female, ng/dL
14-15 years: 6-52 ng/dL
16-17 years: 9-58 ng/dL
18-39 years: 9-55 ng/dL(.000,000,000,090 - .000,000,550g/mL or .36-2.2mcg in 4-6L of blood)
40-59 years: 9-55 ng/dL
60 years and older: 5-32 ng/dL

Male Free Testosterone, pg/mL
12-13 years: 0.5-98.0 pg/mL
14-15 years: 3-138.0 pg/mL
16-17 years: 38.0-173.0 pg/mL
18 years and older: 47-244 pg/mL(.000,000,000,047 - .000,000,000,244g/mL or .188-1.464mcg in 4-6L of blood)

Serum Total Testosterone Male, ng/dL
12-13 years: 3-619 ng/dL
14-15 years: 31-733 ng/dL
16-17 years: 158-826 ng/dL
18-39 years: 300-1080 ng/dL (.000,000,003 - .000,001,080g/mL or 12-18mcg in 4-6L of blood)
40-59 years: 300-890 ng/dL
60 years and older: 300-720 ng/dL
http://www.aruplab.com/guides/ug/tests/0081056.jsp

molar mass of Testosterone 288.42g/mol
SHBG is ~90,000g/mol
albumin is ~60,000g/mol

so with a huge range of 4-6L of blood in a person.
20pg = .000000020g
4L = 4000mL
20pg * 4L = 80mcg of Free testosterone in an small man
25pg * 4L = 100mcg of Free testosterone in an small man
20pg * 6L = 120mcg of Free testosterone in an large man
25pg * 6L = 150mcg of Free testosterone in an large man

[/quote]
If there was a food/vitamin/drug that would free the innactive testosterone, then you would probably get a big effect there too.


I'm thinking, pheromone chapstick for men, and at levels of 1mcg/application might work with testosterone.