NP17
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RE: Eliminating A-1 Depression
11-06-2015 11:16 AM
(11-06-2015 11:08 AM)dsouza Wrote: Where did you buy it from (post link) and did you break out in zits?
Did it eliminate lethargy or just depression? I don't get depression much from AM or L2k v1.. But I do get terrible lethargy from l2k v1 in subsequent days.. Sometimes the lethargy doesn't hit till 2 days later!!!
I think I used this one. It was a while ago.
http://www.vitaminshoppe.com/p/enzymatic...jzfsLerTIU
I see now on the vitamin shoppe website that you can get 100 mg tablets for pretty cheap.
http://www.vitaminshoppe.com/p/jarrow-fo...es/jf-1034
I did not get acne, but I have gotten that in the past from DHEA and pregnenolone.
I consider lethargy a different manifestation of A-1 depression, so yes it eliminated the lethargy for me.
As for side effects, it would be best to scale up your dose to see how much you need and not take it every day if you don't have to.
Also, this website is interesting:
http://www.raysahelian.com/7-ketodhea.html
Dr. Ray Sahelian warns about the side effects of hormones. Here's a counter-argument he posted on his website:
Quote:Q. As an adjunct instructor of nutrition and head of technical services for a private label supplement manufacturer I read a lot of company's information as well as numerous scientific journals. I was on your site, which I enjoy very much as you always have good science-based information, and noticed some negative comments made about the use of 7-keto. I'm confident based on the extensive research of Henry Lardy, PhD Professor Emeritus Biochemistry, University of Wisconsin, Madison of the safety of 7-keto. He and others have published numerous studies demonstrating its safety and efficacy. Some of the subjective information provided on your website cannot serve as a basis for a decision on whether or not to use it. One study that I can give you the reference for demonstrates the safety of 7-keto (I have an extensive list of other studies). I hope you get a chance to review Dr. Henry Lardy's work and others.
I would like to respond to the statement from your website regarding 7-oxo DHEA (7-Keto). The combination of my graduate studies in nutrition, undergraduate studies in biology and chemistry and working in the nutraceutical industry has offered me the opportunity to meet and or speak with numerous researchers in various fields. I would like to share with you some of the published research on 7-oxo-DHEA, and hope to convince you of the safety and efficacy of this compound. There is nobody more qualified, in my mind, to speak on anything related to DHEA then Dr. Henry Lardy, Professor Emeritus, Institute for Enzyme Research, Department of Biochemistry, University of Wisconsin, Madison. As I’m sure you already know, the University of Wisconsin Madison has several researchers, both present and former, who have made major contributions to the fields of nutrition and biochemistry i.e. Michael Pariza, CLA research, Hector Deluca, vitamin D, James Ntambi, fatty acid biochemistry to name a few. With regard to your statement that “if 7 Keto DHEA has testosterone like benefits, it is likely that certain 7-keto DHEA side effects will be due to androgen excess”. Dr. Lardy and others have repeatedly shown that 7-Keto is a metabolite of and not a precursor to, either estrogen or testosterone. The positive metabolic effects reported for 7-oxo DHEA (7-Keto) are due to its ability to influence thermogenic enzymes i.e. malic enzyme to a greater extent than DHEA (without increasing testosterone and estrogen). 7-oxo DHEA (7-Keto) has been shown to be safe and effective in individuals (both healthy and overweight) at a dose of 200 mg/day.
Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers.
Clin Invest Med. 2000
Twenty-two healthy men received placebo or 3-acetyl-7-oxo-DHEA at 50 mg/d for 7 days followed by a 7-day washout; 100 mg/d for 7 days followed by a 7-day washout; and 200 mg/d for 28 days. Safety parameters, evaluated at each dose level, included measurement of total testosterone, free testosterone, dihydrotestosterone, estradiol, cortisol, thyroxin and insulin levels. Analyses for 7-oxo-DHEA-3beta-sulfate (DHEA-S), the only detectable metabolic product of the administered steroid, were conducted on plasma drawn from all subjects. The administered steroid was not detected in the blood but was rapidly converted to 7-oxo-DHEA-S, the concentrations of which were proportional to dose. This steroid sulfate did not accumulate. The mean time to peak plasma level of 7-oxo-DHEA-S was 2 hours; the mean half life was 2 hours.
A. [by Dr. Ray Sahelian - NP17] Over decades of review of nutritional studies I have come to realize the significant shortcomings that occur in safety studies due to several possible factors: The researchers did not look specifically for certain side effects, the patients did not report them, the researcher was supported by the company whose product is being tested and hence positive results are promoted and negative outcomes minimized (this occurs more often than people realize). For instance studies with DHEA rarely mention hair loss or heart rhythm disturbances but this occurs quite frequently among users. I find that the best way to evaluate the benefits and side effects of medications and nutritional supplements is to review the published research, take account my own experiences and feedback from patients, and read the emails I get from people who have used these products. Relying on studies alone does not provide the full picture.
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Eliminating A-1 Depression
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